KAMUT®는 건강에 미치는 유익성 및 안전성을 확인하기 위하여 시험관시험, 동물시험, 인체시험을 시행하였으며
이에 대한 결과 논문을 유명 과학지(SCI/E급)에 발표하여 시험의 신뢰성을 확보.
약 20편의 연구자료를 보유한 특정 브랜드의 곡물로는 유례가 없음.
| 임상과제 | KAMUT의 항산화 및 당뇨 예방의 속성에 대한 평가 (Evaluation of antioxidative and diabetes-preventive properties of an ancient grain, KAMUT® khorasan wheat, in healthy volunteers) |
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| 학회지 | European Journal of Nutrition(https://doi.org/10.1007/s00394-017-1579-8) https://www.ncbi.nlm.nih.gov/pubmed/29143934 |
| 임상구분 | 인체적용 시험(a randomized, non-blind, parallel arm study) |
| 식품유형/섭취기간 | 남성 Fusilli : 350 g/1주, Penne: 350g/1주, Bread: 420g/1주 Biscuits: 300g/1주, Crisp toasts: 180g/1주, Crackers: 100g/1주 (섭취기간: 16주) 여성 Fusilli : 250 g/1주, Penne: 250g/1주, Bread: 300g/1주 Biscuits: 150g/1주, Crisp toasts: 100g/1주, Crackers: 100g/1주 (섭취기간: 16주) |
| 결과 | ① 체-지방량 저하(fat mass): b = 3.7%; CI 1.6-5.5; p = 0.042 ② 인슐린(insulin) 저하: b = 2.4 µU/ml; CI 0.2-4.2; p = 0.036 ③ DHA 증가: b = - 0.52%; CI - 1.1 to - 0.12; p = 0.021 |
| 결론 | Our study provides evidence that a substitution diet with KAMUT® khorasan wheat products can reduce some markers associated to the development of type-2 diabetes compared to a diet of modern wheat. |
| 임상과제 | KAMUT의 특성과 심혈관질환 위험인자에 대한 대체식의 영향 (Characterization of Khorasan wheat (Kamut) and impact of a replacement diet on cardiovascular risk factors) |
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| 학회지 | European Journal of Clinical Nutrition (2013), 1–6; doi:10.1038/ejcn.2012.206 https://www.nature.com/articles/ejcn2012206 |
| 임상구분 | 인체적용 시험(cross-over dietary intervention study) |
| 식품유형/섭취기간 | Pasta: 500g/1주, Bread: 150 g/1주, Cracker: 500g/4주, Biscuit: 1kg/4주 섭취기간: 8주 (1일 KAMUT 섭취량: 140.5g) |
| 결과 | ① 총콜레스테롤 저하, LDL 콜레스테롤 저하 ② 혈당저하(blood glucose) ③ 항산화(산화스트레스): TBARS, Carbonyl levels 등의 redox 상태 개선 ④ 항염: IL-6, IL12, TNF-α, VEGF와 같은 전 염증성 cytokines 수치 저하 ⑤ 혈중 “칼륨(K)”, “마그네슘(Mg)” 증가 |
| 결론 | The present results suggest that a replacement diet with Kamut products could be effective in reducing metabolic risk factors, markers of both oxidative stress and inflammatory status. |
| 임상과제 | KAMUT 대체식의 특성과 심혈관질환 위험인자에 대한 효과 (An Organic Khorasan Wheat-Based Replacement Diet Improves Risk Profile of Patients with Acute Coronary Syndrome) |
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| 학회지 | Nutrients 2015, 7, 3401-3415; doi:10.3390/nu7053401 http://www.mdpi.com/2072-6643/7/5/3401 |
| 임상구분 | 인체적용 시험(a randomized crossover trial) |
| 식품유형/섭취기간 | Pasta: 500g/1주, Bread: 150 g/1주, Cracker: 500g/4주, Biscuit: 1kg/4주 섭취기간: 8주 (1일 KAMUT 섭취량: 140.5g) |
| 결과 | ① 총콜레스테롤 저하, LDL 콜레스테롤 저하 ② 혈당저하, 인슐린(insulin) 저하 ③ 항산화(활성산소, 지질과산화, 항염, 산화스트레스) ④ 종양괴사인자(Tumor Necrosis Factor-alpha) 감소 |
| 결론 | The present study shows that the ancient organic khorasan wheat has an additive protective effect by further down-regulating several key parameters/markers, including those considered important for secondary prevention of ACS. This protection is not afforded by conventional control wheat. |
| 임상과제 | 장내 세균 및 대사체에 대한 KAMUT 영향 (Impact of Kamut® Khorasan on gut microbiota and metabolome in healthy volunteers) |
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| 학회지 | Food Research International 63 (2014) 227–232 https://www.sciencedirect.com/science/article/pii/S0963996914002440 |
| 임상구분 | 인체적용 시험(a randomized, non-blind study) |
| 식품유형/섭취기간 | Pasta: 118g/1일, Baked goods: 88g/1일 섭취기간: 3개월 |
| 결과 | ① SCFA(short chain fatty acid) 및 페놀화합물(phenol compound) 방출 ② 건강을 증진하는 장내 미생물의 공생생물의 증가 ③ 셀레늄(Se)에 의한 항염, 산화스트레스 중화 작용 ④ B. pseudocatenulatum B7003 and L. plantarum L12의 생장을 촉진 |
| 결론 | The release of SCFA and phenol compounds, as well as by a slight increase in health-promoting mutualists of the gut microbiota in comparison to whole durum wheat adopted as a control diet. The high concentration of selenium in Kamut® Khorasan-based foods, these results may contribute to support our previous in vivo findings related to the anti-inflammatory activity and counteraction of oxidative stress |
| 임상과제 | 과민성대장증후군에 대한 KAMUT 효과 (Effect of Triticum turgidum subsp. turanicum wheat on irritable bowel syndrome) |
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| 학회지 | British Journal of Nutrition (2014), 111, 1992–1999 https://www.ncbi.nlm.nih.gov/pubmed/24521561 |
| 임상구분 | 인체적용 시험(a double-blinded randomised dietary intervention trial) |
| 식품유형/섭취기간 | Pasta: 500g/1주, Bread: 150g/1일, Cracker: 500g/4주, Biscuit: 1000g/4주 섭취기간: 6주 (1일 KAMUT 섭취량: 140g) |
| 결과 | ① IBS 증세(1복통, 2복부팽만감, 3대변 일관성, 4피로감) 감소 ② 소화기계 증상(1통증의 정도, 2통증의 빈도, 3복부 팽만) 개선 ③ 염증전구물질(pro-inflammatory cytokines) 감소 ④ IL-6, IL-17, interferon-g, monocyte chemotactic protein-1 and vascular endothelial growth factor |
| 결론 | A replacement diet with ancient khorasan wheat consumption provided additive protection in reducing total and LDL cholesterol, insulin, blood glucose, ROS production, and some inflammatory risk factors, which are all key factors warranting of control in secondary prevention of T2DM compared to a diet with products made with modern wheat. |
| 임상과제 | KAMUT 대용식 섭취에 의한 비알코올성 지방간 환자의 Risk profile 개선 (A Khorasan Wheat-Based Replacement Diet Improves Risk Profile of Patients With Nonalcoholic Fatty Liver Disease (NAFLD)) |
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| 학회지 | Journal of the American College of Nutrition 37(6):508-514 · April 2018 https://doi.org/10.1080/07315724.2018.1445047 |
| 임상구분 | 인체적용 시험(a randomized, double-blind, parallel-arm study) 임상대상: 비알코올성 지방간 환자 40명(남성:12/여성:28/연령:55세 전후) |
| 식품유형/섭취기간 | 1일 섭취량: 140 g dry weight (pasta, bread, crackers, biscuits) 섭취기간: 3개월 |
| 결과 | ① 지방간 위험인자 감소 alanine aminotransferase (ALT): 12% 감소 aspartate aminotransferase (AST): 14% 감소 alkaline phosphatase (ALP): 8% 감소 ② 항염증, 항암, 면역, 항산화 pro-inflammatory tumor necrosis factor-alpha(전-염증성 종양괴사인자): 50% 감소 interleukin l-receptor antagonist-alpha(인터루킨 면역 억제 인자) : 37% 감소 interleukin-8(염증 활성 인자): 24% 감소 interferon gamma(염증성 질환 발현 인자): 24% 감소 (특히 결핵균 검사에 적용) |
심혈관 질환 관련 인체시험: 콜레스테롤 및 항산화Characterization of Khorasan wheat (Kamut) and impact of a replacement diet on cardiovascular risk factors: cross-over dietary intervention study Eur J Clin Nutr. 2013 Feb; 67(2): 190–195. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260112/) EUROPEAN JOURNAL OF CLINICAL NUTRITION (SCI: NATURE PUBLISHING GROUP/England) / ISSN: 0954-3007 E-ISSN: 1476-5640
급성관상동맥증후군 인체시험: 콜레스테롤 및 항산화An organic khorasan wheat-based replacement diet improves risk profile of patients with acute coronary syndrome: a randomized crossover trial Nutrients. 2015 May 11;7(5):3401-15. doi: 10.3390/nu7053401. (https://www.ncbi.nlm.nih.gov/pubmed/25970146) NUTRIENTS (SCIE: MPDI/Switzerland) / ISSN: 2072-6643 E-ISSN: 2072-6643
혈류/행 역학 효과 인체시험: 혈행 및 항산화Short-Term Hemodynamic Effects of Modern Wheat Products Substitution in Diet with Ancient Wheat Products: A Cross-Over, Randomized Clinical Trial Nutrients. 2018 Nov; 10(11): 1666. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266695) NUTRIENTS (SCIE: MPDI/Switzerland) / ISSN: 2072-6643 E-ISSN: 2072-6643
제2형 당뇨 효과 인체시험: 혈당조절, BMI, 항산화A khorasan wheat-based replacement diet improves risk profile of patients with type 2 diabetes mellitus (T2DM): a randomized crossover trial Eur J Nutr. 2017 Apr;56(3):1191-1200. (https://www.ncbi.nlm.nih.gov/pubmed/26853601#) EUROPEAN JOURNAL OF NUTRITION (SCIE: SPRINGER HEIDELBERG/Germany) / ISSN: 1436-6207 E-ISSN: 1436-6215
항산화 및 당뇨 효과 인체시험Evaluation of antioxidative and diabetes-preventive properties of an ancient grain, KAMUT® khorasan wheat, in healthy volunteers Eur J Nutr. 2019; 58(1): 151–161. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424920/) EUROPEAN JOURNAL OF NUTRITION (SCIE: SPRINGER HEIDELBERG/Germany) / ISSN: 1436-6207 E-ISSN: 1436-6215
비알코올성 지방간: 지방간, 항산화/염 인체시험A Khorasan Wheat-Based Replacement Diet Improves Risk Profile of Patients With Nonalcoholic Fatty Liver Disease (NAFLD) J Am Coll Nutr. 2018 Aug;37(6):508-514. (https://www.ncbi.nlm.nih.gov/pubmed/29652567) JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION (SCI: ROUTLEDGE JOURNALS/England) / ISSN: 0731-5724 E-ISSN: 1541-1087
과민성대장증후군 관련 인체시험Effect of Triticum turgidum subsp. turanicum wheat on irritable bowel syndrome: a double-blinded randomised dietary intervention, cross-over trial Br J Nutr. 2014 Jun 14;111(11):1992-9. (https://www.ncbi.nlm.nih.gov/pubmed/24521561) BRITISH JOURNAL OF NUTRITION (SCI: CAMBRIDGE UNIV PRESS/England) / ISSN: 0007-1145 E-ISSN: 1475-2662
Prebiotics 효과: 장내 유익균 활성화Prebiotic effect of soluble fibres from modern and old durum-type wheat varieties on Lactobacillus and Bifidobacterium strains J Sci Food Agric. 2012 Aug 15;92(10):2133-40. (https://www.ncbi.nlm.nih.gov/pubmed/22298124) JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (SCI: WILEY/USA) / ISSN: 0022-5142 E-ISSN: 1097-0010
장내 유익균 활성Impact of Kamut® Khorasan on gut microbiota and metabolome in healthy volunteers Volume 63, Part B, September 2014, Pages 227-232 (https://doi.org/10.1016/j.foodres.2014.04.005) FOOD RESEARCH INTERNATIONAL (SCI: ELSEVIER SCIENCE BV/Netherland) / ISSN: 0963-9969 E-ISSN: 1873-7145
비-셀리악/소아지방변증 대상 글루텐민감증에 대한 중화작용Role of Kamut® brand khorasanwheat in the counteraction of non-celiac wheat sensitivity and oxidative damage Volume 63, Part B, September 2014, Pages 218-226 (https://doi.org/10.1016/j.foodres.2014.01.065) FOOD RESEARCH INTERNATIONAL (SCI: ELSEVIER SCIENCE BV/Netherland) / ISSN: 0963-9969 E-ISSN: 1873-7145
비-셀리악/소아지방변증 대상 글루텐민감증에 대한 혈액단핵세포의 반응Responses of peripheral blood mononucleated cells from non-celiac gluten sensitive patients to various cereal sources Food Chem. 2015 Jun 1;176:167-74. (https://www.ncbi.nlm.nih.gov/pubmed/25624220) FOOD CHEMISTRY (SCI: ELSEVIER SCI LTD/England) / ISSN: 0308-8146 E-ISSN: 1873-7072
산화스트레스 동물시험: 항산화Role of cereal type and processing in whole grain in vivo protection from oxidative stress Front Biosci (Landmark Ed). 2011 Jan 1;16:1609-18. (https://www.ncbi.nlm.nih.gov/pubmed/…) FRONTIERS IN BIOSCIENCE-LANDMARK (SCIE: FRONTIERS IN BIOSCIENCE INC/USA) / ISSN: 1093-9946 E-ISSN: 1093-4715
항산화 동물시험Counteraction of oxidative damage in the rat liver by an ancient grain (Kamut brand khorasan wheat) Nutrition. 2012 Apr;28(4):436-41. (https://www.ncbi.nlm.nih.gov/pubmed/22129853) NUTRITION (SCI: ELSEVIER SCIENCE INC/USA) / ISSN: 0899-9007 E-ISSN: 1873-1244
항산화 및 항염 동물시험Antioxidative and anti-inflammatory effect of in vitro digested cookies baked using different types of flours and fermentation methods Volume 88, Part B, October 2016, Pages 256-262 (https://doi.org/10.1016/j.foodres.2015.12.010) FOOD RESEARCH INTERNATIONAL (SCI: ELSEVIER SCIENCE BV/Netherland) / ISSN: 0963-9969 / E-ISSN: 1873-7145
장내 유산균 활성시험Improving the functional and sensorial profile of cereal-based fermented foods by selecting Lactobacillus plantarum strains via a metabolomics approach Volume 89, Part 3, November 2016, Pages 1095-1105 (https://doi.org/10.1016/j.foodres.2016.08.044) FOOD RESEARCH INTERNATIONAL (SCI: ELSEVIER SCIENCE BV/Netherland) / ISSN: 0963-9969 / E-ISSN: 1873-7145
건강유익성 논평Ancient wheat and health: a legend or the reality? A review on KAMUT khorasan wheat International Journal of Food Sciences and Nutrition 68(3):1-9 • October 2016 (https://www.researchgate.net/…/309540055_Ancient_wheat_and_…) INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION (SCIE: TAYLOR & FRANCIS LTD/England) / ISSN: 0963-7486 E-ISSN: 1465-3478
20년간 KAMUT 경작물의 영양소 및 영양기능성 연구Nutritional and nutraceutical aspects of KAMUT® khorasan wheat grown during the last two decades Journal of Agricultural Science, Page 1 of 12. © Cambridge University Press 2017 (https://www.cambridge.org/core/journals/journal-of-agricultural-science/article/abs/nutritional-and-nutraceutical-aspects-of-kamut-khorasan-wheat-grown-during-the-last-two-decades/0E15002402C7D114F34627550FB0A9EB)
흰쥐 체내에서 혈중 대사 인자에 미치는 영향 (삼육대학교)Analysis of the General and Mineral Compositons of Kamut Powder and Efect of Kamut (Tritcum turanicum Jakubz) Powder and Its Efect on Blod Parameters in Mice Fed a High-Fat Diet Suplement Korean J. Food Nutr. Vol. 30. No. 6, 157~163 (2017) https:/doi.org/10.979/ksfan.2017.30.6.157
